Nolan Arenado started things off with a two-out solo homer in the first. According to Statcast-, the ball traveled an estimated 384 feet with an exit velocity of 104 mph. The Rockies added three more runs in the third on a pair of run-scoring hits from Mark Reynolds and Ian Desmond. Charlie Blackmon plated the fifth run with a single in the fourth.
Full Game Coverage
All five runs were charged to Santana, who labored through seven innings on the mound. He allowed six hits, striking out three and walking four. As a result, Santana's ERA went from 1.50 to 2.07. Meanwhile, the only blemish for Colorado's Marquez, who earned the victory, came in the fifth inning on a sacrifice fly by Brian Dozier.
MOMENTS THAT MATTERED
Streak snapped: Marquez's scoreless streak of 10 consecutive road innings was snapped in the fifth. However, the frame nearly got away from him entirely. Following a one-out triple by Eddie Rosario and a Byron Buxton walk, Dozier put the Twins on board with a sacrifice fly to left. Marquez then walked Joe Mauer before ultimately getting Miguel Sano to pop up on a curveball to end the inning.
Free pass: The Twins elected to intentionally walk Arenado his second time up in the third inning, which proved to be detrimental. The next batter, Reynolds, smacked a two-seam fastball down the left-field line to drive in two runs. He was later thrown out at home by Max Kepler to end the inning, but Reynolds -- who is among the leaders in the National League in with 35 RBIs -- was a key part in breaking the game completely open.
Shane Jackson is a reporter for MLB.com based in Minneapolis.
Thomas Harding has covered the Rockies since 2000, and for MLB.com since 2002. Follow him on Twitter @harding_at_mlb and like his Facebook page.
This story was not subject to the approval of Major League Baseball or its clubs.